New Vaccine Development

Common diseases cost the developing world an enormous amount in terms of human life, health, and productivity, as well as lost economic potential. New and effective vaccines could not only improve the quality of life for millions of residents in developing countries, they could also contribute substantially to further economic development. Using data from the World Health Organization and other international agencies, this book analyzes disease burdens, pathogen descriptions, geographic distribution of diseases, probable vaccine target populations, alternative control measures and treatments, and future prospects for vaccine development. New Vaccine Development provides valuable insight into immunological and international health policy priorities.Table of ContentsFront Matter1. Summary2. Priority Setting for Health-Related Investments: A Review ofMethods3. Overview of the Analytic Approach4. Comparison of Disease Burdens5. Predictions of Vaccine Development6. Assessing the Likely Utilization of New Vaccines7. Calculation and Comparison of the Health Benefits andDifferential Costs Associated with Candidate Vaccines8. Additional Issues in the Selection of Priorities for AcceleratedVaccine Development9. Findings, Conclusions, and RecommendationsAppendix A: Selection of Vaccine Candidates for AcceleratedDevelopmentAppendix B: The Burden of Disease Resulting from Acute RespiratoryIllnessAppendix C: The Burden of Disease Resulting from DiarrheaAppendix D-1: The Prospects for Immunizing Against Dengue VirusAppendix D-2: The Prospects for Immunizing Against EscherichiacoliAppendix D-3: The Prospects for Immunizing Against Hemophilusinfluenzae Type bAppendix D-4: The Prospects for Immunizing Against Hepatitis AVirusAppendix D-5: The Prospects for Immunizing Against Hepatitis BVirusAppendix D-6: The Prospects for Immunizing Against JapaneseEncephalitis VirusAppendix D-7: The Prospects for Immunizing Against MycobacteriumlepraeAppendix D-8: The Prospects for Immunizing Against NeisseriameningitidisAppendix D-9: The Prospects for Immunizing Against ParainfluenzaVirusesAppendix D-10: The Prospects for Immunizing AgainstPlasmodium spp.Appendix D-11: The Prospects for Immunizing Against Rabies VirusAppendix D-12: The Prospects for Immunizing Against RespiratorySyncytial VirusAppendix D-13: The Prospects for Immunizing Against RotavirusAppendix D-14: The Prospects for Immunizing Against SalmonellatyphiAppendix D-15: The Prospects for Immunizing Against Shigellaspp.Appendix D-16: The Prospects for Immunizing Against StreptococcusGroup AAppendix D-17: The Prospects for Immunizing AgainstStreptococcus pneumoniaeAppendix D-18: The Prospects for Immunizing Against VibriocholeraeAppendix D-19: The Prospects for Immunizing Against Yellow FeverAppendix E: Questionnaire for Assessing Morbidity-MortalityTrade-OffsAppendix F: Technical NotesAppendix G: Biographical Notes on Committee MembersAppendix H: Additional Sources of Advice to the CommitteeAppendix I: Contents of Supplement to Volume IIAppendix J: Preface to Volume IAppendix K: Contents to Volume IIndex