New Developments in Oncology Research

In the opening chapter, authors discuss the current literature that describes the application of Palliative Medicine services in advanced cancer, models of Palliative Care delivery by site and mode of practice, cost-effectiveness of early Palliative Medicine referral patterns and national and international Palliative Medicine practice and referral guidelines. The chapter will also discuss the outcomes of Palliative Medicine in Oncology focusing on the improvements in patient clinical and quality of life outcomes. Next, a systematic chapter aims to better explain the mechanisms that underlie electrolyte disturbances in cancer patients, to stress on the serious prognostic implications involved and to provide practical and useful indications for the prompt diagnosis, management, and therapy of electrolyte disorders. The authors discuss over thirty Pt{I 2-P(X)nP}Cl2 (n = 5,6,7,8) derivatives in which organodiphosphines create wide varieties of the metallocyclic rings: eight-membered (PC5P, PC2OC2P, PC2NC2P), nine-membered (PC6P, POC4OP), ten-membered (POC5OP, PC2OCOC2P, PC3OC3P), and eleven-membered (PC8P, PNC6NP, POC6OP). Another included study covers eighty five Pt(II) complexes with an inner coordination sphere of cis- PtP2Cl2. The P- donor ligands are organodiphosphines which create four- and five-membered metallocyclic rings with the PCP, PNP, PC-CP, PC=CP, PN2P and PCOP types. In the penultimate chapter, the authors examine over forty cis-Pt(I 2-PXXXP)Cl2 derivatives in which organodiphosphines create six-membered metallocyclic rings, and the concluding chapter examines over thirty cis-Pt(I 2-PXXXXP)Cl2 derivatives in which organodihosphines create seven-membered metallocyclic rings.