Misfolding of Amyloid-beta and tau in Alzheimer’s and Other Neurodegenerative Diseases

Misfolding of Amyloid-beta and tau in Alzheimer’s and Other Neurodegenerative Diseases describes historical discoveries of these two major proteins in Alzheimer’s disease and other neurodegenerative conditions. The book navigates through the importance of protein self-assembly, protein conformational change, and structural studies in understanding the positioning in the disease pathway. How these proteins are involved in the pathway to neuronal dysfunction, and the importance of understanding protein conformation and deposition for diagnosis are also highlighted. Although Alzheimer’s disease was discovered over 100 years ago, the role of protein misfolding in the pathology and cause of Alzheimer’s disease remains unclear. Amyloid-beta and Tau are both proteins well known for their involvement in Alzheimer’s disease. Both proteins misfolding and aggregate are deposited as cross-beta amyloid fibrils in the tissues.