LC-MS/MS Method Development Troubleshooting Roadmap

LC-MS/MS Method Development Troubleshooting Roadmap

By Mirela Gorjanu

Struggling with poor peak shape, unstable signals, or failing QC samples?

This book is your go-to troubleshooting companion for LC-MS/MS method development, validation, and routine analysis, designed for real-world lab challenges, not textbook theory.

Inside this practical roadmap, you'll discover:Step-by-step flowcharts to solve common LC-MS/MS problems fastExpert tips for rescuing methods with low signal, drift, or noiseSolutions for retention time shifts, matrix effects, and failing accuracyReal lab scenarios, checklists, and ready-to-use protocolsTools to troubleshoot during live validation, production, or auditsWhether you're a pharmaceutical scientist, bioanalytical chemist, or QC analyst, this field-tested resource helps you save time, reduce rework, and gain confidence with LC-MS/MS troubleshooting under pressure.

BONUS: Includes daily system suitability checklists, case studies, and a glossary of essential LC-MS/MS terms.