Bioinformatics

Bioinformatics is a field of study that integrates biological sciences with computer science. This book is the first of its

kind written for students and teachers. It gives the readers an insight into genomics and proteomics including origin

and history of bioinformatics, computer generations, their types and operating systems, role of PERL and JAVA as

programming languages, central dogma of molecular biology, with structural details of DNA, RNA, and proteins and

fundamental techniques used to study their structures, the database retrieval with PubMed, Entrez, SRS, OMIM,

ExPASy, and EMBL, the BLAST and FASTA software packages to determine sequence matches, the computational

methods for gene prediction, protein sequence databases, Swiss-Prot, PDB, software for visualization of protein

structure, and the concepts of gene, genome and genomics with the prime role of GenBank, DDBJ, TIGR, KEGG

genomics of bacteriophage to HGP, gene therapy, drug designing and pharmacogenomics. Several web pages with

their specific URLs are provided that will definitely help readers to interact and learn more about cutting-edge

research and visualize complex processes involved in bioinformatics.

Contents

IntroductionEvolution of ComputersBiological MacromoleculesBasic Techniques in BioinformaticsBiological DatabasesSequence AlignmentMultiple Sequence AlignmentsComputational Gene PredictionProteomicsGenomics