Analysis of the Threat of Genetically Modified Organisms for Biological Warfare

Evaluating the potential threat posed by advances in biotechnology, especially genetically modified organisms (GMOs), and synthetic biology remains a contentious issue. The rapid development of the tools of molecular biology and metabolic engineering has enabled the development of chimeric organisms which possess characteristics which are not native to the wild variant. This is commonplace in the area of biomanufacturing, where genes are introduced into organisms such as E coli and products manufactured via large-scale fermentation. More recently, entire metabolic pathways, albeit of limited complexity, have been engineered into organisms, for example, for the production of artemisinin in yeast.2 In addition to such metabolic engineering projects, whole genomes are being sequenced, leading to the possibility of creating organisms de novo.